Sentence examples for suppression of translation from inspiring English sources

This suggests that for some genes, selection may be operating in parallel on synonymous codon usage and uORFs to reduce translational efficiency, and that suppression of translation efficiency may be a more important mechanism of eukaryotic gene regulation than currently appreciated.

In this study, we deliberately designed siRNAs that simultaneously direct cleavage and translational suppression of HIV RNAs, or cleavage of the mRNA encoding the HIV coreceptor CCR5 and suppression of translation of HIV.

This is the first report describing the general suppression of translation across the entire transcriptome of the cell.

Mature miRNAs operate via sequence-specific interactions with the 3' untranslated region (UTR) of cognate mRNA targets, causing suppression of translation and mRNA decay [1], [2].

The suppression of translation by miRNA/RISC has been linked to the presence of the eIF6 anti-association factor (which prevents the assembly of the 80S ribosome) [33].

The second response involves suppression of translation mediated by the serine/threonine kinase PERK, which phosphorylates and inactivates the translation initiation factor eIF-2α to reduce the production of misfolded proteins [10], [11].

A few transcripts encoding ribosomal proteins were all downregulated, which indicate a suppression of protein translation, although a translation initiation factor and a tRNA synthetase were both upregulated.

In addition to the selective suppression of GATA1 translation discussed above, selective suppression of globin translation has been reported in RP-deficient zebrafish (Zhang et al., 2014).

Antisense oligonucleotides owe their efficacy to an ability to induce RNase H-dependent suppression of RNA translation, for sufficient time to allow physiological proteolysis.

HSPCs cocultured with either of these exosomes exhibited impaired clonogenicity, through the miR-150– and miR-155 mediated miR-155 mediatedhe transuppressiontranscripts encofing c-MYB, a thenscriptranslation invofved in HSPC differentranscripts prolifencoding

Alternatively, mismatched dsRNAs can lead to reduced gene activity through the suppression of protein translation [4].