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In BT-474 cells, siRNA oligos induced HER2 downregulation (Supplementary Figure S5a) and obvious suppression of activities of HER2.
The higher EC50 of WT RyR2 is likely due to the suppression of activities at 10 100 μM Ca2+ in the absence of Mg2+.
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Interestingly during mental imagery, primary visual and auditory cortices showed modality-specific suppression of activity.
Chronic suppression of activity triggered changes in PSD interior architecture that may help amplify synaptic plasticity.
Cortical spreading depression (CSD) is a wave of neuronal depolarization and follwed by suppression of activity, which has been implicated in the pathophysiology of migraine aura.
Short-term suppression of activity did not have an impact on the size of the MFT, however, longer-term suppression reduced the overall size of the MFT.
In particular, an area at the end of the basal ganglia, the globus pallidus, steps up its suppression of activity in other brain regions.
Midbrain values returned to normal immediately after the cessation of nicotine exposure and then showed a subsequent, transient suppression of activity.
It might be the suppression of activity of transponible elements [5], [6].
Suppression of activity ratios (SR) were calculated as (test activity)/ test+baseline activity), which normalizes for hyper- or hypo-activity.
Our results show that for each luciferase reporter construct, at least one miRNA produced a significant suppression of activity (Figure 2).
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