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Immune suppression has been shown to be mediated in part by a suite of immunomodulatory proteins actively secreted by the nematodes6,7.
Expressive suppression has been shown to be negatively correlated with well-being [5].
HIPK2 is a transcriptional co-repressor, and its suppression has been shown to inhibit chemotherapeutic drug-induced apoptosis [46].
Reduced expression of developmentally important genes and tumor suppressors due to haploinsufficiency or epigenetic suppression has been shown to contribute to the pathogenesis of various malignancies.
MicroRNA suppression has been shown to decrease the protein level produced from some mRNAs without changing the mRNA steady state levels [30].
Punishment-induced response suppression has been shown to be dependent on the central, but not the basolateral nucleus of the amygdala (Killcross et al. 1997).
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Based on a pathway-specific approach, multiple TSGs across pathways including cell cycle regulation, JAK/STAT signalling, WNT signalling, and DAP kinase-associated intrinsic tumour suppression have been shown to be inactivated by gene hypermethylation in leukaemia, lymphoma and multiple myeloma [3], [4], [5], [6], [7], [8], [9], [10], [11].
Similar effects of AP-1 blockade on growth suppression have been shown in one out of four breast cancer cell lines and in a colon cancer cell line (Ludes-Meyers et al, 2001; Suto et al, 2004).
This perspective has been derived from EEG studies in which bursts and suppressions have been shown to occur concurrently across the scalp (Clark and Rosner, 1973).
Involvement of DNA methylation in CXCL12 gene suppression (CXCL12) has been shown in malignancy and some autoimmune diseases.
Additionally statin induced suppression of RhoA has been shown to inhibit peritoneal dissemination of ovarian cancer cells in vivo [ 31].
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