We find no evidence for the reiteration of early stomatal lineage behaviors in these GCs, nor do we find suppression of divisions in the GC precursor.
ML141 exposure also enhanced the ability of TMX to suppress BLBC cell growth, through both induction of cell death and suppression of cell division.
Along with the microarray findings presented in Tables 1 and 2, and compared to appropriate controls, these data suggest GIPC1 suppression promotes cell division arrest and apoptosis.
Our findings highlight the complex nature of the AZT effect on airway cells, which involves up-regulation of lipid/cholesterol biosynthetic pathways, suppression of cell division pathways, and specific modulation of inflammatory genes, including down-regulation of mucin production.
In fact, sulA, the central cell division suppression protein of the SOS pathway, is reduced in expression by more than two-fold over the course of 4 hours, while lon, which deactivates sulA, increases in expression during that same period of time.
Dexamethasone, a synthetic glucocorticoid that induces hepatic gluconeogenesis, promotes the expression of hepatocyte phenotype through the suppression of cell division [ 28].
The number of HN2-treated cells was decreased by 72 h, indicating both suppression of cell division and induction of cell death (Supplementary Figure S3).
Inhibition of Cdc42 also greatly enhanced TMX-induced suppression of cell division, as analysed by labelling cells with monoclonal Ki67 antibody.
Studies in vitro using 293T endothelial vascular cells, have shown that expression of this gene caused suppression of cell division [ 42].
