Sentence examples for suppressing the binding from inspiring English sources
The obtained results demonstrate the importance of systematically suppressing the binding energy for competing ligands.
Our results clearly showed that treatment of RA-FLSs with COE suppressed IL-1β and TNF-α-induced cell migration and invasion, and revealed that COE inhibited the transcriptional activity of MMP-9 by suppressing the binding activity of NF-κB in the MMP-9 promoter, and inhibited IκBα phosphorylation and NF-κB nuclear translocation.
It has previously been shown that RUNX3 binds to TCF4/β-catenin complex, which suppresses the binding of the complex to the Wnt target gene promoters.
Their interactions, however, seem to differ as CPC binds stronger to GL3 [ 41] and suppresses the binding of GL1 to GL3 more efficiently than TRY [ 14].
Nfd suppressed the binding of Zn and Cu to MTs and led to a decrease in Lactate/Pyruvate ratio and elevated protein carbonylation indicating pro-oxidant conditions.
As shown in Fig. 2D, a dose of 4 micrograms of sc-68920 suppressed the binding of PAB046 and PAB050 by 30% compared to the control non-inhibited PAB variants (100%) and this decrease is statistically significant as verified by ANOVA (indicated by asterisks).
The results indicate that while the aromatic ring plays an important role in promoting protein binding under high-salt conditions, moieties associated with intermediate hydrophobicity (e.g. aliphatic side chain) or the presence of hydrogen bond donors (e.g. NH and OH) tended to suppress the binding.
Soluble heparin suppressed the binding of VEGF-A and surface heparin dose dependently (Figure 5B).
Several studies have demonstrated that CpG methylation of CRE sites suppresses the binding of transcription factors and represses gene expression [27] [29].
Neither dl-histidine nor histamine suppressed the binding of Him-Suc-GSYK.
In Arabidopsis, PTI suppressed the binding of Auxin-responsive TFs to the promoters of downstream genes, hence down-regulating the auxin-response pathway [ 57].
