Recent studies by Szeto et al. [42] indicate that by suppressing lymphocyte activation, minocycline treatment reduces HIV replication in CD4+ T lymphocytes.
Recently, it has been observed that the HDL complex is capable of suppressing lymphocyte function, particularly in the host resistance to tumors [22].
Functional characterization of BM-MSCs and ASCs has shown that both cell types do not express HLA-DR (of the major histocompatibility complex class II, MHC II), which renders these cells significantly less immunogenic than other cell types, while they are also capable of suppressing lymphocyte reactivity in mixed lymphocyte reaction (MLR) assays and reducing inflammation in vivo [ 8, 15, 20– 23].
On the other hand, for the islets co-encapsulated with PTX and then exposed to lymphocytes solution till 7 days, the external environment was totally transparent, indicating that PTX can easily suppress lymphocytes attack on encapsulated islets.
Thus, biomaterials have recently been applied to autoimmunity to stop these reactions by destroying (deletion) or inactivating (anergy) pathogenic cells, or by expanding specialized TREGS which are able to suppress lymphocytes reactive against self-molecules such as myelin.
Bartholomew, A. et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo.
CD4+ splenocytes after MHC therapy suppress lymphocyte proliferation against donor antigens in vitro.
Sudres, M. et al. Bone marrow mesenchymal stem cells suppress lymphocyte proliferation in vitro but fail to prevent graft-versus-host disease in mice.
4-(Nitrophenyl)hydrazone derivatives of N-acylhydrazone were synthesized and screened for suppress lymphocyte proliferation and nitrite inhibition in macrophages.
Dried plum also suppressed lymphocyte tumor necrosis factor (TNF -α producTNF -αx vivo by sproduction, in rexponse to concanavivon (Con) A stimulation.
In mice, lactate injection suppressed lymphocyte cytotoxic responses [29].
