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In conclusion, our study demonstrates that miR-34 may restore, at least in part, the tumor suppressing function of p53 in p53-deficient human pancreatic cancer cells.
Our results demonstrate that miR-34 may restore, at least in part, the tumor suppressing function of the p53 in p53-deficient human pancreatic cancer cells.
Our study demonstrates that miR-34 may restore, at least in part, the tumor suppressing function of p53 in p53-deficient cancer cells.
However, recent biochemical and cellular studies indicate that mammalian SMYD2 protein is an H3K36-specific HMT [63], and surprisingly, that it is able to methylate p53 on the lysine 370 and thereby inhibit the tumor suppressing function of p53 [64].
Both processes might contribute to the tumor suppressing function of FancJ.
It may retrieve the tumor suppressing function of the p53 in p53-deficient human pancreatic cancer cells [ 39].
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This suggests that HNF4α exhibits tumour suppressing functions [ 101].
These tumor suppressing functions of FBLN1 corresponded with its loss of expression in bladder cancers.
Genes with metastasis suppressing functions in other tumor entities did not show evidence of assuming the same role in PDAC.
MAX is MYC's dimerization partner and is required for both the transcriptional activating and suppressing functions of MYC [ 28].
One common outcome of AS events is suppressed function of a gene by the production of non-functional transcripts, which can be achieved through the NMD mechanism [ 50- 53].
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