The stability diagram indicates that the regions of the chatter-suppressing dynamics expand with increasing tool rake angle and decreasing tool clearance angle.
In order to achieve the chatter-suppressing dynamics in hard ultrasonic vibration cutting, a stability diagram is predicted based on the simulated work displacement for tool geometry changing.
Recently published data showed that excessively rapid microtubule dynamics as well as suppressed dynamics were associated with resistance to paclitaxel in a human lung cancer line (Goncalves et al, 2001).
Low concentrations of paclitaxel that suppressed dynamics; hence, they did not affect the rate of microtubule detachment; but the higher drug concentrations that allowed normal cell division strongly inhibited detachment in the mutant cell lines and returned the rate to near normal levels.
The aim of this paper is to address the problem of suppressing unstable dynamics occurring in rectangular natural circulation loops on the base of a reliable model-based controller.
However, treatment of cells with low concentrations of taxol (10 n M) has been suggested to induce a mitotic block by suppressing microtubule dynamics rather than by altering the microtubule polymer mass or inducing bundle formation (Jordan et al, 1993).
Taxanes, however, act specifically during the G2/M phase of the cell cycle, blocking cell cycle progression by impairing centrosome formation, inducing abnormal spindles, and suppressing microtubule dynamics during spindle development.
Anti-mitotic agents inhibit cell proliferation by suppressing microtubule dynamics [ 13]; however, based on immunofluorescence staining images, we found that KT-NB did not disrupt the microtubule organization in interphase or spindle formation during mitosis, indicating that it is not a microtubule destabilizing agent.
Treatment with taxol, which suppresses microtubule dynamics and activates the spindle checkpoint, revealed a specific switch in kinetochore architecture.
Metaphase chromosome positioning depends on Kif18A, a kinesin-8 that accumulates at and suppresses the dynamics of K-MT plus ends.
Compounds that bind at the colchicine site of tubulin have drawn considerable attention with studies indicating that these agents suppress microtubule dynamics and inhibit tubulin polymerization.
