Sentence examples for suppresses the clock from inspiring English sources
Because an elevation of Usf1 expression is most likely responsible for suppression of the Clock Δ19 /+ phenotype, we sought to determine the mechanism by which USF1 suppresses the Clock phenotype.
Analysis of period in these crosses suggests that the BALB allele acts semidominantly to suppress the Clock Δ19 mutation.
A SNP in the promoter of Usf1 causes elevation of its transcript and protein in strains that suppress the Clock mutant phenotype.
Thus, USF1 can suppress the Clock Δ19 mutant by increased occupancy of CLOCK BMAL1 E-box sites, acting as a partial agonist for CLOCK BMAL1-mediated transCLOCK BMAL1-mediated
Moreover, a moderate overexpression of USF1 from a transgene driven by the minimal CMV promoter in B6 mice suppressed the Clock mutant phenotype in a similar fashion as the BALB Usf1 allele.
Ikeno et al. suppressed the expression of the clock genes cycle and period by injecting bean bugs with double-stranded RNA (RNAi), showing by northerns that this achieved at least partial downregulation of the targeted gene, and also a reduction in per mRNA after cyc RNAi treatment, which would be expected as a secondary consequence of reduced levels of CYC.
There are folks actively trying to roll back the clock by suppressing people's votes, by seeing to it that multitudes of poor people and people of color don't have access to the American political system.
Six of the clock genes were suppressed by the cytokine in ways that would, in an actual animal, be expected to promote sleep.
Thus SIK1 provides negative feedback, acting to suppress the effects of light on the clock.
As SIK1 acts to suppress the effects on light on the clock, this pathway presents a tractable target.
Recent results show that TOC1 suppresses transcription of multiple target genes within the clock circuit, far beyond its previously-described regulation of the morning transcription factors LHY (LATE ELONGATED HYPOCOTYL) and CCA1 (CIRCADIAN CLOCK ASSOCIATED 1).
