Indeed, aviation development in the U.S. was suppressed to such an extent that when the U.S. entered World War I no acceptable American-designed airplanes were available, and U.S. forces were compelled to use French machines.
When PTEN is active and AKT activity is suppressed, FoxO proteins are able to enter the nucleus and upregulate genes that promote cell cycle arrest or apoptosis [3].
However, the expression of the protein products encoded by these genes is not acutely suppressed even though the cells fail to enter S-phase [57].
Moreover, COR could suppress stomatal defence, allowing the pathogen to enter host tissue [ 21].
She graduated from Carthage College in nearby Carthage, Illinois (now in Kenosha, Wisconsin), in 1879, and, suppressing for a time her long-standing wish to enter the ministry, she then taught school for four years in Iowa.
97 Furthermore, a SIRT1 NLS mutant unable to enter the nucleus failed to suppress colony formation, whereas SIRT1-overexpressing cells showed a strong inhibitory effect.
It allows molecules to enter the interstitial tumor space, by suppressing the lymphatic filtration making it possible to keep the molecules in the malignant cells.
These results showed that activation of Klotho can suppress the proliferation of nucleus pulposus cells and may induce cells to enter a resting phase, the G0 phase.
The Saudis rallied the Persian Gulf monarchies to support the Sunni monarchy in Bahrain in brutally suppressing the protests — and put Iran on notice that they were "ready to enter war with Iran and even with Iraq in defense of Bahrain".
In contrast, stimulating the neurons of the central thalamus more slowly – around 10 times a second – suppressed the activity of part of the brain called the sensory cortex and caused rats to enter a seizure-like state of unconsciousness.
The enhanced permeability and retention (EPR) effect is a phenomenon unique to and ubiquitous in tumors which allows macromolecules such as lipids to enter the tumor interstitial space (enhanced permeability) where they are sequestered due to suppressed lymphatic filtration (retention).
