It is possible that an actively expressed gene can suppress the expression of a close-by gene, especially a weakly expressed gene.
We used siRNA molecules to suppress the expression of LRPPRC in HeLa cells stably expressing GFP LC3 (HeLa-GFP-LC3).
MiRNAs can suppress the expression of target genes through translational repression or through degradation of a target's transcript.
RBM24 also enhances the interaction of Core and 5′-UTRs of HCV RNA, which suppress the expression of HCV.
Thus, RBM24 may also suppress the expression of HCV through its interaction with Core but not NS3 protein.
Compared with the control cells, native IFN-CSP and mu-IFN-CSP treated obviously suppress the expression of HBsAg.
Exosomes shed from acute myeloid leukemia cells suppress the expression of a hematopoietic transcription factor in the bone marrow.
In this study, we demonstrated that miR-875 and miR-3144 could suppress the expression of both exogenous E6 and endogenous E6 by directly targeting E6 ORF.
Antisense transgenic approach was exploited to suppress the expression of OsPPR1 and the obtained transgenic lines displayed chlorophyll-deficiency, albinism and lethality.
In this process, double-stranded RNAs (dsRNAs) can suppress the expression of target genes in a homology-dependent manner (Hannon, 2002; Almeida and Allshire, 2005).
To validate whether TGF-β-induced apoptosis is Bim dependent, we used the siRNA system to suppress the expression of Bim.
