Sentence examples for suppress maturation from inspiring English sources

Finally, glucocorticoids suppress maturation, differentiation, and proliferation of immune cells, including innate immune cells, T cells, and B cells.

PTH has been shown to act via the type 1 PTH receptor to induce matrix synthesis and suppress maturation of chondrocytes [ 70].

Moreover, in vivo TRAIL treatment led to enhanced metastasis in an orthotopic xenograft model of pancreatic cancer and TRAIL-R2 expression in the same model might promote tumor cell proliferation by suppressing maturation of the microRNA let-7.

For example, the human SKI-like (SKIL) gene encodes the SMAD transcriptional corepressor SNON that antagonizes TGF-β signaling and suppresses maturation of chondrocytes by mediating signal cross-talk between TGF-β TGF-βone morphogenetic protein (BMP) pandways [ 77].

In our experimental dry-eye model, in which wild-type mice are subjected to a drafty low-humidity environment, and lacrimal gland secretion is pharmacologically inhibited [ 22, 40], we demonstrated that IL-13 is a homeostatic factor for conjunctival goblet cells, whereas IFN-γ suppresses maturation of these cells [ 41].

Since glioma cells suppress the maturation of DCs, GCLRP-associated DC maturation is an important step in eliciting an effective antiglioma immune response.

Substantial inhibition of endometrial cellular proliferation would retard the development of a secretory endometrium and suppress endometrial maturation [ 80], thus making successful implantation unlikely.

Tumors not only suppress DC maturation but they can also induce the development of DCs with regulatory function, that actively display immunosuppressive activity themselves.

Stronger females suppress the maturation of weaker females after winter [ 5, 25] adults suppress the maturation of young females in late summer, both in enclosed [ 26- 28] and in wild populations [ 29].

They suppress the maturation of DC and the ability of DC to produce inflammatory cytokines as well as T helper-type 1 (Th1 -promoting cyTh1 -promotings IL-12p70 [6]–[9].

Rather, a single allele in heterozygous state must somehow actively suppress pollen maturation.