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Our data suggests that it will also be important to consider the N-glycan profile of Treg as this may influence the ability of Treg to home correctly in vivo to sites where they mediate suppression, regardless of their ability to suppress in an in vitro MLR.
Our previous study also demonstrated that the suppression of Pyk2 by PRNK domain in MHCC97L cells can suppress in vivo intrahepatic tumor growth and venous invasion as well as extrahepatic lung metastasis [15].
It is possible that CD44- subset and CD44+ subset of CD25+ Tregs suppress in different manner, which is why one cannot abrogate suppression by neutralizing TGF-β and IL-10 in cultures with both the subsets so far.
Additionally, chondrocytes suppress, in a contact-dependent manner, the proliferation of activated T cells, with suppression associated with chondrocyte expression of multiple negative regulators of immune responses, including B7 family members (B7-H1, B7-DC, B7-H3, B7-H4, and B7-H4), chondromodulin-I and indoleamine 2,3-dioxygenase.
Machiavelli is supposed to have said that gambling is something to encourage in your enemy's country but suppress in your own.
How ironic that those in opposition should resort to threats of violence to suppress, in the putative interest of science, a discussion of religion.
The judge granted the defense motion to suppress in March 1996, after a six-month trial that ended in May 1995; the state dropped its last appeal in April 1999.
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Since 5 to 25% of PTC-containing mRNAs fail to elicit NMD and are consequently translated into truncated proteins [32], several therapies have been developed specially to suppress in-frame PTC [33], [34].
The list was suppressed in June 1966.
The revolt was suppressed in 345 bce.
Armed Islamic movements have been suppressed in Egypt and Algeria.
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