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As a consequence of their ability to significantly suppress acid secretion, PPIs are the preferred class of therapeutic agents for the treatment of GERD.
Drugs which are known to suppress acid (Proton pump inhibitors and H2 blockers) or alter esophageal motility (anticholinergics, sedatives, antihypertensive and anti-angina drugs) were discontinued 2 weeks before inclusion.
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These drugs are amazingly effective at suppressing acid.
AdipoRs and AMPK signaling suppress fatty acid synthesis by inactivating ACC and FAS and stimulate fatty acid oxidation.
CRABP2 has been shown to function both to suppress retinoic acid receptor activity by sequestering ligands and also as a vehicle to deliver ligands to the retinoic acid receptors, thereby enhancing ligand-mediated retinoic acid receptor transcriptional activity [ 40- 45].
Upregulation of ACLY activity in tumor cells expressing activated Akt could suppress fatty acid oxidation (through increased acetyl-CoA and malonyl-CoA production), thus supporting the significant requirement for lipid synthesis in proliferative cell states.
SST is persistently released between meals to suppress interprandial acid secretion (2, 8).
DCA appeared to suppress lactic acid production from pyruvate in both cancer and non-cancerous cells.
The use of H2RAs can suppress gastric acid production by 37 to 68% over 24 hours [ 20].
Indeed, fibrates suppress bile acid synthesis, the major pathway of cholesterol elimination from the body [ 8, 9].
Infusion of glucose-insulin-potassium (GIK) has been used to increase myocardial glucose uptake and glycolysis (and suppress fatty acid oxidation) protect against IRI.
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