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Huey Freeman, the hero of "The Boondocks" and McGruder's supposed alter ego, has not cracked a smile in five years of syndication.
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Signing with the Mets was supposed to alter that career trend, and a three-game stint at Class AAA Norfolk was supposed to remake Trachsel into a winner.
At best, it was supposed to alter the country's economy permanently, by strengthening domestic demand as a counterweight to the more unpredictable export cycle.
"The consequence of a misdemeanor is not supposed to alter someone's life to the point where they can't earn a living or it affects their job," said Joseph Tacopina, who represented Hiram Monserrate, the former state senator, in his assault case in Queens.
How is a teacher supposed to alter the way in which they teach a child who cannot concentrate because the parents don't feed him/her properly?
Limit caffeine, take folic acid supplements, monitor physical exertion the list of ways women are supposed to alter their lives to accommodate for their growing fetuses is long, and mostly reasonable.
Therefore, the difference at the 5'end between isomiRs is supposed to alter isomiRs' target genes.
TNFα blockade, when retarding disease progression in some selected target interphalangeal joints, was not supposed to alter residual hand function and pain caused by multiple deformities that previously occurred in other finger joints.
(Trivia: If a bottle says it has a lot of thujone, it probably doesn't -- absinthe makers who emphasize the alcohol's supposed "mind-altering" properties have their eye on taking tourists' money).
Moreover, these ranges are supposed to be altered with other genotypes.
Gap junctional communication likely is necessary for synchronised detrusor contractions and is supposed to be altered in voiding disturbances.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com