Our strongest evidence supports determinant roles for Ubp7p and Art5p, related to ubiquitin-mediated proteolysis; stress response transcriptional repressor, Nrg1p; and NADPH-dependent glutamate dehydrogenase, Gdh1p.
Of these isolates, ≥70% contain at least one mutation in UBP7, ART5 and either of the GDH1 mutation loci, which further supports determinant roles for these genes on the phenotype.
The GS population sequencing data support determinant roles in HWSSL tolerance for a large portion of the mutated R57 genes based on their pervasiveness throughout the evolving populations.
This analysis also yields an additional SNP that falls within the area of PCR amplification, affecting SSA1266 bp upstream of the R57 mutation and leading to a D22G missense mutation, which further supports a determinant role for SSA1 in the observed phenotype.
Table 7 illustrates how select CWH tools/materials are linked to and shown to support a determinant and, in turn, how the determinant is linked to and is shown to support a performance objective.
Two cross-sectional surveys revealed technical support as determinant of electronic health records acceptance [ 45, 74].
Social support as determinant of health is complex and closely interwoven with other factors, including socio-economic and cultural factors [ 41, 42].
Although some of the remaining R57 mutations may be of interest based on the known functions of the affected genes, sequencing of GS populations did not support a determinant effect on HWSSL tolerance for every mutation.
Our data supporting the determinant effect of RPGR isoforms in the subcellular localization of RPGRIP1α1 is in apparent contradiction with reports of transgenic mice with endogenous expression of RPGRIP1 lacking the C2 and RID, but still retaining its upstream domains (Rpgrip1 tm1Tili) (Won et al., 2009; Zhao et al., 2003), and mice lacking the expression of Rpgr (Hong et al., 2000).
[4] both determined that fear of movement/reinjury are supported as determinants of function after ACLR, neither assessed the influence of relevant impairments routinely assessed in clinical practice (i.e., single-leg hop capabilities, quadriceps strength, and anterior knee joint laxity) in conjunction with fear of movement and reinjury in their patient populations.
[4] both previously determined that fear of movement/reinjury are supported as determinants of function after ACLR, neither assessed the influence of relevant impairments routinely assessed in clinical practice in conjunction with fear of movement and reinjury in their patient populations.
