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To investigate whether our new method was supportive of conclusions (i) and (ii) or not, we first grouped the sampling locations into 6 regions R1,..., R6 as shown in Figure 3.
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This is supportive of conclusion (i), i.e. that R6 is probably a melting-pot.
Our own study is a modest addition to the dataset of prospectively derived data and is supportive of earlier conclusions but it is still necessary to conduct larger randomized trials of DEX in AWS.
While the number of embryos we examined is not sufficient to reach statistical significance, the results are highly supportive of our conclusions from the Mesp1Cre-MADM analysis.
The in vivo data are consistent with, though not strongly supportive of, our conclusions regarding the combination of phenoxodiol and cisplatin.
Our findings of higher risks of death from ischemic heart disease, arteriosclerosis, cerebrovascular disease, and peripheral vascular disease are supportive of these conclusions.
Secondly, we have moved this analysis of the 144 accessions and corresponding figure to the end of the Results as it was only meant to be supportive of our conclusions and it became obvious from all the reviewers comments that having it near the beginning was giving it dramatically more weight than expected.
While the number of embryos we looked at is not statistically significant, we believe performing a full analysis using the Smarcd3-F1CreERT2; Confetti system in addition to the Mesp1 Cre -MADM system is beyond the scope of this paper, but that the current data are highly supportive of our conclusions with the MADM system.
Analysis of the electrostatic surface of CifPl and CifBp (Fig. 3) and the localisation of conserved residues (labelled black in Fig. 4(a)) in this region is supportive of this conclusion.
The subgroup analyses in our updated meta-analysis for epoetin- β are fully supportive of this conclusion.
On the other hand, the independence of variables used in linkage is often questionable, in which case the lower predictive ability of the individual variables is at the very least supportive of our conclusion.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com