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Mutations at H221, D223, H277 and R287 completely abolished enzymes activities, supporting their importance in binding ferrous iron and 2-oxoglutarate.
These features are highly conserved throughout metazoan evolution, supporting their importance in orchestrating the splicing reaction with efficiency and fidelity.
Genome-wide association studies also uncovered common variants for liver-related traits that were enriched for the CRMs found in more than one species, further supporting their importance.
Overall, it appeared that both inflammatory and haemostatic stimuli affected expression of genes involved in inflammatory and haemostatic pathways, supporting their importance in equine joint diseases.
The features that point to such active participation of XBP1 mRNA in the splicing reaction are highly conserved throughout metazoan evolution, supporting their importance in orchestrating XBP1 mRNA processing with efficiency and fidelity.
While 12 GOI are included in that pathway, 8 of these genes were also identified by other analyses used to identify GOI, further supporting their importance to the post-TBI IR.
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Kharaka et al.[79]do not rule out the possibility of other important groups of organic ligands but the observational data are not available to support their importance in modern basinal brines and ancient ore fluids.
The down-regulation during recovery of genes encoding aquaporins, supports their importance in stress tolerance.
Our results further support their importance in the metastasic process in BC.
Thus, our observations support their importance for pluripotency (Tahiliani et al., 2009).
Much evidence supports their importance in causing and sustaining cell transformation in model systems and in human cancer.
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CEO of Professional Science Editing for Scientists @ prosciediting.com