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Although the possibility that the observed effect of sorafenib is a consequence of cell death that cannot be completely ruled out, it has to be mentioned that higher concentrations of sorafenib are required for induction of apoptosis in two LNCaP sublines which express increased AR levels (Culig et al. 1999), thus supporting the conception that AR inhibition by sorafenib precedes cell death.
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An exceptionally generous benefactor, Ruth and her husband Jerome supported the conception and construction of the College's visual arts center which opened in 2004.
JB and RBP supported the conception of the research design and data analysis.
CIDAUT has developed this research as part of the project to support the conception of a new driver assistance system, aimed at improving longitudinal driving by means of information, warning and intervention strategies.
Overall results support the conception of career adaptability as a self-regulatory resource that may promote a virtuous cycle in which individuals' evaluations of their resources to cope with the environment (i.e., career adaptability) shape their affective states, which in turn influence the evaluations of their job.
According to available models, the results indicate that the optimal layout of mini-ORC turbines can substantially differ from that of radial-inflow turbines utilized in more traditional applications, strengthening the need of experimental campaigns to support the conception of new design practices.
The observation of Xist RNA foci within the partially collapsed ANC supports the conception of Xist RNA interacting with chromatin representing genes or regulatory elements.
Our results support the conception that the biological mediators found in cancer microenvironments have a significant impact on the ability of cancer cells to metastasise.
Together, these data support the conception that the Rb-E2f pathway is downstream of Rage signaling and critically contributes to altered gene transcription during TPA-induced skin inflammation.
For example, the widespread distribution of putative virulence determinants in the faecal baby isolates supports the conception of enterococcal virulence, not as a result of any single virulence factor but as a more complex process [ 11].
The widespread distribution of putative virulence determinants in the fecal baby isolates in this study supports the conception of enterococcal virulence, not as a result of any single virulence factor, but as a more complex process.
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