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The endothelial molecule S-Endo 1 antigen (CD146) is preferentially located at endothelial junctions and has been claimed to support endothelial integrity.
Taken together, our data might shed some light on early vascular events prior to the establishment of macrovascular endothelial dysfunction: Under homeostatic conditions, EC-derived kinins support endothelial function and vascular integrity autocrinally and via the recruitment of angio-supportive cells, mainly mediated by the B2R [9].
Fig. 1: Mitochondrial respiration supports endothelial proliferation.
prTE supported endothelial cell growth with typical endothelial cell cobblestone morphology after 48 h in culture.
miR-221/222 are primarily implicated in maintaining endothelial integrity and supporting quiescent EC phenotype.
We therefore conclude that initially, the lack of paracrine support provided to EC by recruited cells, rather than actively inflicted damage, contributes to the loss of endothelial integrity in T1D.
This finding, which is in accordance with the previously reported correlation between OPG and vascular calcification and mortality, provides additional support on its association with early atherosclerosis, and might indicate a clinically relevant effect of OPG on endothelial integrity.
Xiong, Y. & Hla, T. S1P control of endothelial integrity.
Scanning electron microscopy in the evaluation of endothelial integrity of the fatty lesion in atherosclerosis.
Increased apoptosis may contribute to the loss of endothelial integrity and leads to cardiovascular disease.
At present, effective therapeutics to restore endothelial integrity are barely available.
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