The system supports data generated by perturbing the expression of specific genes, portrays views of the network during development, and lays out network models.
SplitSeek is strict with regard to the format of the input data and only supports data generated by ABI SOLiD.
The lack of effect of cortisol in the proliferation assay (Figure 5B) is supported by data generated by time-lapse imaging with direct observation of endothelial cell proliferation which showed that proliferation is not a key component of TLS formation in this model.
The process of budding of PMP-containing vesicles from the ER proposed by van der Zand et al. (2010) is supported by data generated by Lam et al. (2010), who used a cell-free in vitro vesicle-budding assay.
This result supports the data generated by qPCR and strongly suggests that PRL mRNA expression is not induced in a minor subset of human breast cancer cells within the same tumour, which might have been missed using the qPCR technique.
Such possibility is supported by data generated by us and others demonstrating that recombinant WT TTR purified at 4°C or at 37°C has different cytotoxic potential which might indicate that the protein may have at least two alternative tetrameric conformations with different stability [ 13, 15].
These results lead to the conclusion that all strains of rabies virus isolated from humans during the rabies outbreak in northern Brazil in 2004 are related to the D. rotundus variant commonly found in Brazil, which supports the data generated by antigenic typing.
The benefits of combining perifosine and CCI-779 is further supported with in vivo data generated by treating mice with GBMs for 5 days before harvesting tumor tissue for immunoblot and IHC analysis.
This propagation of internal scenario consistency does not occur automatically, but can be actively supported by the use of data generated by the CIB,28 as well as by the active work of CIB advocates, meaning actors representing and following the CIB, for instance during the writing of narrative storylines and during the translation into numerical scenarios.
Although these schemes did not yield a larger overlap of tissue-specific genes, we anticipate that improved pre-processing procedures can support the consolidation of the data generated by different microarray data sets.
