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To address this challenge we previously developed a generic knowledge management framework, BioXM™, which allows the dynamic, graphic generation of domain specific knowledge representation models based on specific objects and their relations supporting annotations and ontologies.
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Ontology terms are selected for the Entity, Quality, and (optionally) Related Entity fields, thus supporting annotation of both monadic and relational characters.
An 'Add Phenotype' button (+ on Phenotypes panel, Figure 5) facilitates the entry of multiple phenotypes for a single character state, thus supporting annotation of composite characters.
The lacZ gene expression patterns and supporting annotation might allow stem cell researchers to explore the gene expression profiles of in vivo stem cell compartments in greater depth.
The service supports annotations, threaded comments on film, and time stamped comments.
The environment did not support annotations in the visual representation thereby avoiding problems with visual clutter.
Additional data used to support annotations included prediction of trans-membrane helices using TMHMM [41], prediction of signal peptide with signalP [42], lipoprotein motif and Clusters of Orthologous Groups (COG) [43].
SBML, like BCML, supports annotations that can be added to elements using a controlled vocabulary.
Also, expression studies can seldom support annotations to a Cellular Component or Molecular Function term.
Those types of annotation transfers may result in increasing levels of specificity of annotations, even for proteins already having experimentally supported annotations.
Text mining for GO annotation might thus expand to include not only predictions for experimentally supported annotations but also predictions for other annotations supported by the text of a paper such as those described from previously published results.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com