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Except for the MTHFR C677T (rs1801133) and MTHFR A1298C (rs1801131) polymorphisms, for which there are data supporting a recessive model, we assumed a log-additive model to assess genotype/adenoma associations.
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Our meta-analysis supports that individuals carrying the Arg/Arg genotype have a higher cancer risk as assessed in a recessive model.
The most parsimonious model was a recessive model for high bilirubin levels that occurred in about 23% of the population.
For APOC3 m482 a recessive model was applied and for APOC3 3u386 a dominant model was applied.
The odds ratio (OR) for this SNP was 2.80 [CI 1.77 4.44] for a recessive model.
A recessive model for rs628977 (which fits the data, p = 0.55) increased the significance (p = 0.003).
A recessive model was chosen for genotype (del/del patients vs. all other patients).
No significant association was observed when applying a recessive model (P = 0.37).
However, rs2468844 was associated with cIMT only in a recessive model after multivariate adjustment (P = 0.011).
Studying a recessive model of CHD in this population is therefore feasible.
The association of -7202A/G with hospital mortality or with ALI did not improve if a recessive model was used.
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