Sentence examples for supporting a rationale from inspiring English sources

This mechanism is completely different from how classical ESAs function, supporting a rationale for using sotatercept as a new therapeutic agent to manage anaemia in diseases of ineffective erythropoiesis, such as β-Thalassaemia, Diamond-Blackfan Anaemia (DBA), or MDS.

These data demonstrate a role for IL-21 in the modulation of collagen-specific T-cell responses and the pathology of arthritis, supporting a rationale for blockade of the IL-21 pathway in rheumatoid arthritis.

These results support a rationale for manipulating Treg to enhance cancer immunotherapy.

Additional findings may support a rationale for the development of further studies to test the hypothesis that the effects of leptin replacement may improve cognition in leptin-sufficient patients with delay or decline of cognitive function.

These findings therefore support a rationale for targeting the death receptor pathway, as a strategy for bypassing platinum resistance.

Together, these results support a rationale for screening in liquid media to uncover different and potentially novel components of iron metabolism in yeast.

Thus, these studies provided compelling evidence that the presence of Tregs are neuroprotective and support a rationale for Tregs immunotherapy in patients with ALS.

The design of our observational methods implied compromises that did not support a rationale for calculating intra-observer repeatability and inter-observer reproducibility based on correlation statistics.

110 More studies need to be conducted to assess the full role of IL-6 in conferring chemotherapeutic resistance, but these preliminary studies may support a rationale for using combination therapy of IL-6 inhibitors along with classical chemotherapeutic agents.

Nevertheless, the low incidence of severe nonspecific toxic effects of these agents enhances their overall appeal and supports a rationale for preferentially focusing on the development of these agents.

This observation is consistent with the findings of others that have used lower therapeutically efficacious doses [ 34, 35] and support a rationale for application of lower doses of Sunitinib to avoid augmented invasive or metastatic potential.