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High cytoplasmic expression correlated significantly with poor histological differentiation, advanced stage, and worst patient outcome (P < 0.05), supporting a more specific and aggressive treatment.
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Although none of those found in this study seemed to be prognostically significant, they may support a more specific selection of patients for future trials.
In this iteration of the work the initial MAS evolved to support a more specific architecture, enabling the system to make decisions based not only in current data but analyzing the event as a whole taking also into consideration previous changes.
These observations were further supported by a more specific comparison of metabolism using MapMan.
Our classifier placed PfCLK-2 [EupathDB PF14_0408] in the CMGC group but did not find support for a more specific family.
Other positively charged ligands, such as polyamines and divalent cations, bind to this region as well, but by orders of magnitude weaker than SERF1a (Fernández et al., 2004; Nielsen et al., 2001), in support of a more specific role of the latter.
PPV and PNV support our hypothesis that WC is a more specific than sensitive index.
In this respect, the statement that the second UBA-domain accounts for the differential activity between Usp5 and Usp13 is not really supported by evidence (this would need a more specific swap of UBA-domains, rather than large protein segments).
The burden of care experienced by caregivers was large, but our questionnaires were insufficient to support a more detailed understanding of the specific reasons behind this burden.
It makes the conceptualization of VP use more explicit and supports a more precise communication about the specific type of VP addressed and allows a clearer focus of future research activities.
That's better, says one of our respondents--especially when that general goal is supported by more specific strategies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com