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We have shown here that the depletion of p120ctn in E-cadherin and P-cadherin-expressing DU145 and MCF10A cells disrupts cell-cell contacts, and increases migration and invasion of DU145 cells, supporting a model where p120ctn acts as an invasion or metastasis suppressor [48].
QH4 folded into a triple-helix and despite a 9 °C lower Tm than H4, the peptides formed plates, thus supporting a model where length of hydrophobic region is the primary determinant of assembly morphology.
Mutation of the UAG sites to UCC reduced binding to MSI1 protein by an order of magnitude or more in each case, supporting a model where MSI1 binding occurs primarily at these sites.
If transmission of P. rettgeri were to occur during the chronic phase of infection, then our results could be interpreted as supporting a model where tolerance alleles have fixed in the population.
We (Harris et al., 2008; 2010) and others (Kovalenko et al., 2007; Cukierman et al., 2009) have shown a direct interaction of claudins with tetraspanins, supporting a model where CD81 claudin-1 receptor complexes define HCV internalization.
The co-expression of Flag-KRT23 and VSV-G-14-3-3 VSV-G-14-3-3 VSV-G-14-3-3 VSV-G-14-3-3 VSV-G-14-3-3al in turnnuclead fractoon, thus experimentally supporting a modeclinere KRT23 expressiof is indeed influencing the VSV-G-14-3-3ε VSV-G-14-3-3ε VSV-G-14-3-3ε VSV-G-14-3-3ε VSV-G-14-3-3ε
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This supports a model where the methylene blue molecules partitioned into hydrophobic pockets of the film.
These data support a model where cholesterol addition restricts Hh diffusion and can transform a leveled signaling activity into a gradient.
These results support a model where conformational changes induced by the ATPase activity of FtsE are directly and specifically transmitted to the amidases via FtsX and EnvC.
This supports a model where a signaling gradient of Wnt/β-catenin is set up by Wnts and localized Dkk1, which mediates a p axis polarization by guiding cell migration toward the prospective anterior in the pregastrula mouse embryo.
Our data support a model where alterations in epigenetic remodelling in cancer cells in early and late replicating loci provide increased probability for cis or trans chromosomal rearrangements based on the nuclear spatial context.
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