A pathogenetic view starting from endometrioma and atypical endometrioma to EAOC seems plausible and supported by the same gene mutations observed in atypical endometriosis and EAOC.
Multiple lines of evidence in support of the same gene provide additional support for their role in the risk of AD; however, in general, these results need to be interpreted with caution and special attention to any sample overlaps, effect size, and direction of effect in the different studies.
Also, this analysis supported the same conclusions.
In support of the " same gene – same subtype" hypothesis, in a study by Waddell et al. the authors noticed that all tumor biopsies from ATM mutation carriers included in their study were classified as luminal (4 lumB and 2 lumA) [ 36].
Furthermore, we can demonstrate that the overlap among the modules can help to discover different functions of the same gene supported by that a gene may participate in different modules reflecting different functionalities.
This finding was very much supported by the determination that the same gene was also mutated in the mutant hit1.
This X chromosome linked transcript (chrX:8564208-8564984) wasupporteded by EST alignments showing the same gene structure.
Altogether, 21 KOGs contained two or more RGC_CAs, and in each case, multiple RGC_CAs within the same gene supported either the Chromalveolata Opisthokonta clade or the Chromalveolata Plantae clade, with the sole exception of KOG100 (supplementary table S6, Supplementary Material online).
The hypothesis that these contigs derive from the same gene was supported by sequence matches against NR proteins.
Their positions in chromosomal regions sharing members of the same gene families support duplications of large blocks, most likely the chromosome duplications that took place in 2R.
