Furthermore, difficulties in obtaining stable CMV-eGFP expressing hESC lines support the inability of the CMV promoter to sustain stable and efficient transcriptional activity in undifferentiated hESCs [9], [11].
Contralateral ER-negative breast cancer occurred more frequently in the TAM group, supporting the inability of TAM to prevent ER-negative secondary tumours as previously described [ 12].
While our findings support the inability of H2S to reduce metabolism in large mammals, these results differ from observations in mice in which H2S inhalation markedly reduced metabolism [ 9, 10, 22].
Additionally, these same cell suspensions completely reduced 10 mM nitrate to equimolar nitrite within 4 h (Fig. 2b), supporting the inability of this organism to distinguish between perchlorate and nitrate when grown with perchlorate.
In addition to the few tested loci, comparative gene organization analysis suggested that the vast majority of failed SNPs involved introns immediately flanking the SNP sites, further supporting the inability of genotyping when SNP is located at the exon-intron boundary or when introns are included in the extension reaction.
Specificity of the interaction of mblC overexpression with antiapoptotic genes is supported by the inability of Diap2 dose reduction to modify the rough eye phenotype.
A role for IKKβ is supported by the inability of etoposide to reduce Bcl-xL in neurons expressing an shRNA targeting IKKβ, or following pretreatment with sodium salicylate, a potent inhibitor of IKKβ (Figs. 6A and 7).
This is further supported by the inability of GLI1 overexpression to rescue the reduced proliferation elicited by S6K1 knockdown.
This hypothesis was further supported by the inability of phosphoric acid (mimicking a phosphopeptide) to block non-specific binding and by its ability to block phosphopeptide binding.
The latter is further supported by the inability of metformin to extend the lifespan of sams-1 mutant worms, which have a 65% decrease in SAMe levels (Walker et al., 2011).
