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Therefore, in this group, mice were pretreated with rDer p 1, 30 min before further percutaneous treatment with rDer p 2. As shown in Fig. 1c, percutaneous pretreatment with cysteine protease rDer p 1 supported sensitization to subsequently applied rDer p 2, rendering Der p 2-specific IgG1.
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The Government of Angola, local authorities, traditional leaders and religious organizations are supporting sensitization efforts through workshops at community level to encourage introduction of locally produced foods.
Co-encounter of Der p 2 or other allergens with proteolytic allergens (cysteine or serine proteases) may support sensitization – particularly the adjuvant function of the cysteine protease Der p 1 in the respiratory sensitization to other allergens (HDM allergens as well as other allergens) has been outlined in several studies (1, 16– 20).
Till date, UNICEF supported HIV sensitization and awareness raising interventions have benefited approximately 1 million adolescents and youth.
The WHO country office also participated in the NTF to advise on design issues and support sensitization of parliament and cabinet members.
Growing evidence supports cutaneous sensitization to food antigens as one possible mechanism leading to the failure to develop or loss of oral tolerance.
These changes ultimately cause alterations in macromolecular synthesis, synaptic transmission, and structural architecture which support central sensitization, a process required for the establishment of long-term pain states.
Current findings support that sensitization mechanisms are involved in pain spreading or pain referral in children with CTTH.
Although the mechanisms underlying the transition from episodic to chronic TTH are not fully understood, the existing literature supports that sensitization mechanisms play an important role [4, 5].
Causes of FM are largely unknown although there is a growing body of evidence to support central sensitization mechanism underlying chronic musculoskeletal pain in these patients [3].
Abnormal brain processing includes sensitization supported by aberrant inter-regional communication and other alterations in both structure and function, including neurotransmitter levels, all of which may ultimately maintain the chronic pain state.
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