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In addition, it provides a detailed explanation to accompany each recommendation, supported by a rationale and relevant evidence where available.
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The choice of subgroups (e.g. 'high-risk' patients) are to be determined a priori and to be supported by a biological rationale, clinical plausibility, social aspects, or other justified factors (Section 5.10 GMTA).
In the first instance, fitting the β × μ product (that correlates with the amplitude of PA signal) versus TC concentration by a power function may appear to the reader somewhat artificial and not supported by a physical rationale.
The majority and dissent disagreed about whether the Arizona law was supported by a permissible government rationale.
During his tenure as governor, Johnson became known for his low-tax libertarian views, adhering to policies of tax and bureaucracy reduction supported by a cost benefit analysis rationale.
The use of galectin-3 radiotracer for detection of thyroid cancer in vivo is supported by a solid molecular rationale [5], [7] [10].
The importance of minimizing overdistension is supported by a compelling physiological rationale and by strong clinical evidence [ 3].
Our findings are supported by a sound biological rationale because they suggest that limb lymphedema is caused by pelvic lymph node dissection.
Such assumptions should be supported by a biologically plausible rationale before specific retinal vascular features are considered as surrogate markers of cerebrovascular damage (International Conference on Harmonisation, 1998).
The rapid implementation of Phase 1 information into large, randomized Phase 3 trials is a clear sign of the power of early studies when these are supported by a strong biological rationale and by highly significant responses.
The use of the prone position is supported by a strong physiological rationale and a significant improvement of the oxygenation status is observed in roughly 70% of ARDS patients [ 6].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com