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Our review of the mechanistic data supported a threshold-based mechanism as the most plausible.
Myrstad and colleagues also found evidence to support a threshold for risk in studying cross-country skiers compared to a general population [12].
That work showed that flies exposed to similarly low doses of radiation didn't have significantly more mutations than control flies, supporting a "threshold model," in which radiation is innocuous below a certain level.
The curved association between 25(OH D and D-dimer, together with the suggestive elevations in fibrinogen and CRP at the extreme of high concentrations observed in this study, could support a threshold effect with the optimal concentration being between 60 and 120nmol/l.
Several additional lines of evidence support a threshold around 0.03: 1. Divergences within vs. among regions: In Figure 2 (see also the Chi2 analyses), the distances calculated among Guianan populations mainly range between 0 and 0.03 whereas the comparisons between Guianan and other South American populations predominantly yielded distance values between 0.03 and 0.07.
The smaller p value in this combined analysis also supports a threshold model.
These observations support a threshold mechanism for carcinogenicity of OTA (threshold corresponds to a dose of about 16,700 ng/kg body weight/day).
However, the substantial increase in the prevalence of moderate retinopathy at A1C levels ≥6.5% supports a threshold level of glycemia that results in retinopathy most characteristic of diabetes.
However, it has been acknowledged elsewhere that the experimental evidence supporting a ' threshold based model' approach to exercise training is lacking [ 11].
However, this threshold seems to have prevailed more because of traditions and less because of scientific merit as no evidence supporting a threshold of 90 mmHg seems to exist.
The apparent linearity at high doses on the logarithmic scale may have led the authors to conclude that their data support a "threshold" surface area of about 20 cm.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com