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The results support the rationale of the pseudo-ring concept and suggest further investigation of A-ring modification in these benzophenones.
Thus our findings have provided experimental evidence to support the rationale of repetitive administration in cancer treatment in order to maximize the demethylating effect.
These findings support the rationale of administering an Ad vector encoding hsFlt3L to dog patients bearing spontaneous gliomas to mount an immune response against the tumor.
These findings support the rationale of selecting these mRNAs as the markers for inflammation.
These data support the rationale of an ongoing phase III study exploring the potential benefit of tifacogin in severe CAP.
The studies generally support the rationale of using COX-2 inhibitor to reduce tumor invasion and metastasis.
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The paper provides further evidence to support the rationale for standardization of diagnostic testing during the construction stages of dwellings, adding to the body of evidence for in-construction testing (iCT) developed by Cardiff Metropolitan University, to reduce instances of the performance gap and its impacts upon occupant comfort, energy costs and carbon emissions.
Among these biomarkers, p53 is the strongest prognostic marker in OPC and p53 in addition to p16 support the rationale to study of de-escalation strategy for OPC.
These and other observations, particularly the recognition that epigenetic changes are the mechanisms affecting several aspects of tumour cell biology, including cell growth, cell-cycle control, differentiation, DNA repair, and cell death, strongly support the rationale for reversal of methylation as an effective treatment strategy for cancer.
The bioassay showed that the majority of the resultant compounds exerted anti-tumor effect against four human cancer cell lines to various extents, which supported the rationale of the design.
The bioassays showed that the majority of the resultant compounds exerted inhibitory effects on HBsAg and HBeAg levels, HBV DNA replication, as well as the growth of four human cancer cell lines to various extents, which supported the rationale of the design.
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