The predicted residue residue contacts for this family of complexes support the tip-to-tip interaction; the coevolution data did not provide any evidence to support the insertion model.
When using the adaptive LASSO approach, an additional weighting parameter δ j (j=1… N ′ ) is specified (within the range of [0,1]) to shrink the regression coefficient β ^ j and thus, support the insertion of the corresponding prior-knowledge gene-to-TF edge into the model.
Choose chocolates that fit the occasion, and are firm enough to support the insertion of skewers or long thin sticks.
Some of those who supported the insertion of the budget responsibility lock utterly dismiss the idea there was any kind of conspiracy to circumvent the party's manifesto approval process, saying it was just the kind of thing that happened in the course of a campaign.
Thus, neither of the two studies supports the insertion or zigzag models.
Because it computes the real 3D distance of the tip of the lag screw to the surface of the femoral head, the presented system supports the insertion of the lag screw in all surgical cases, including eccentric placement of the lag screw.
In combination with strong mapping data, this provides definitive genetic and sequence support that the insertion of the B2 SINE into the proximal 3' UTR is the ultimate cause of the Comt eQTL.
Moreover, while cell cell fusion assays do not correlate with our electrophysiological data or with the stimulatory function of complexins in release, these assays were crucial to establish the functional interplay between complexins and synaptotagmin-1 (Giraudo et al., 2006) and did provide support for the insertion model (Giraudo et al., 2009).
Furthermore, BAR-domain dimers assemble via low affinity interactions into helical structures involving interactions at the tip and the lateral side of the dimer and may thus exert changes in membrane curvature, which often is supported by the insertion of N-terminal amphipathic helices (Shimada et al, 2007; Frost et al, 2008).
Because our Q129 mice closely replicate pathophysiologic processes in the human brain, as supported by the insertion of a single copy gene with its own promoter, the Q129 mice should be an ideal model for exploring possibilities for therapeutic interventions aimed at polyQ diseases.
Clipped support: Number of clipped reads supporting the same insertion position within the predicted insertion interval Interval length: length of the predicted insertion interval, calculated as the distance between the start position of the innermost read in the forward cluster, and the end position of the innermost read in the reverse cluster.
