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Their findings support the essentiality of milk to the survival of mammalian neonates and the establishment of milk secretory mechanisms more than 160 million years ago.
Here, we report gene deletion experiments that support the essentiality of this gene in P. aeruginosa and the identification of a number of small molecule FabG inhibitors with IC50 values in the nanomolar to low micromolar range and good physicochemical properties.
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Transgenic plants expressing various NHX1 transporters showed increased salt tolerance (For details, see a review: Yamaguchi and Blumwald [2005]), supporting the essentiality of Na+ sequestration in salt tolerance (Apse et al. [1999]).
Studies of PGM null mutants or gene transcript reduction by RNAi in eukaryotes such as yeast, protozoa and nematodes lend further support to the essentiality of PGM in these organisms [13], [60], [61].
It has been recently demonstrated that Mtb requires phosphorylated Glc to support mouse infection, suggesting the essentiality of the hexose for the bacterium's metabolism [74].
The essentiality of amino acids and the SAM cofactor supports the relatively ancient introduction of these riboswitches that could be proposed based their wide distribution across bacterial phyla.
The essentiality of these two nodes indicated by the ESM measure is supported by the fact that pro-inflammatory cytokines and inflammation are required for the resolution of infections [ 43].
The essentiality of genes was determined by querying the database of essential of genes [ 31].
The essentiality of hubs and bottlenecks has been debated in the literature with experimental evidence in support of both sides [ 25, 26, 46, 47].
"No one questions the validity, the urgency, the essentiality of the Voting Rights Act," he added.
Utilizing compounds that target lipid metabolism, we affirmed the essentiality of major classes, including triacylglycerols.
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