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This work was partially supported by the Canadian Institutes of Health Research CIHR and Foundationon Fighting Blindness-Canada (funding reference numbers MOP-77750, CIHR RMF-92101).

They thank the Arthritis Research Campaign for their support (grant reference numbers 17552, E0555 and 18066).

This work was supported by Arthritis Research UK (Grant Reference Number 19739 to ICS).

This work was supported by the Swedish Research Council (reference number 2011 3470), the Royal Physiographic Society, the Foundation of the Swedish National Board of Health and Welfare, Carl og Ellen Hertz' legat til Dansk læge- og naturvidenskab, and the Lippman Foundation.

This work was supported by the Integrated Programme Agreement 'METAFOODLABS', reference number S116/2012/537723, funded by the Autonomous Province of Trento and by the research office of the Autonomous Province of Trento.

The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2334/12/210/prepub Thistudydy was supported by Pathology Queensland's Study Education and Research Trust Fund SERTFF reference number: 1932_WeinsteinS).

Funding This study was supported by the NHMRC (project grant reference number 490317).

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SM was supported by the Medical Research Council (MRC file reference number U105178783).

This work was supported by the UK Medical Research Council (MRC file reference number U105184291) and, in part, by Alzheimer's Research UK.

This work was supported by the Bill & Melinda Gates Foundation (grant reference number OPPGH5271).