The truncated topoIIα and topoIIα+β tail proteins were unable to complement, but interestingly the truncated topoIIβ and topoIIβ+α tail proteins were able to support low levels of growth.
Perhaps more surprising is that topoIIβ truncated protein and topoIIβ+α tail protein can support low levels of growth, implying that some localisation to the nucleus is still present.
In vivo complementation data show that the topoIIα C-terminal domain is needed for growth, but the topoIIβ isoform is able to support low levels of growth without a C-terminal domain.
It is therefore unclear why the truncated topoIIβ protein is able to support low levels of growth (and hence localise, albeit inefficiently, to the nucleus), but it is possible that this is due to a presently unknown mechanism, perhaps linked to topoIIβ specific modification, or an unidentified NLS specific to topoIIβ.
Of the psychosocial factors, practicing religion rarely or never, low social support, low levels of trust and high social exclusion were associated with poor PMH among both genders.
In model 2, including sociodemographic and psychosocial factors, living without a partner, practicing religion rarely or never, low social support, low levels of trust and high levels of social exclusion were significantly associated with poor PMH among both genders, independent of sociodemographic factors.
However, we cannot completely rule out that liver cells other than hepatocytes metabolize PCBs in KO mice or that the cytochrome b5 electron transfer pathway may support low levels of P450 enzyme activity, thus resulting in the formation of HO-PCBs.
In other words, a subset of the high level constellation is used as the low level constellation, and this subset depends on the design of NC. (ii) At the receiver side, nodes merely supporting low level modulation first find their constellation according to the a priori information and then perform demodulation and decoding.
We found that Ni2+ could support low-level ciprofloxacin activity against the wild-type enzyme but not against the ParCS80L mutant.
The relative levels of growth support are consistent with the data presented here (where the topoIIα C-terminal domain chimera supports low levels of growth and the topoIIβ C-terminal domain chimera supports no growth at all), although the levels of growth differ, perhaps because of differences in the experimental systems or the sensitivity of methods [27].
Even the combination of the nCRF and the CRF for modelling RGCs could go a long way in supporting low-level filtering models.
