The authors thank Yves Rivière, Florence Buseyne and Ren Zhu for their critical reading of the manuscript and discussions, the patients for their willingness to participate in this study and Estelle Mottez for her support in organizing the trial.
The relative risk of quitting at 6 months for text-based support observed in the trial, 2.20 (95 % CI 1.80 2.68, P < 0.0001), is applied to the quit rate at 6 months in the control group (4.9%%) [ 1].
In terms of cost-effectiveness, the Internet-based support in this trial does not seem to fall within accepted standards for the incremental cost-effectiveness ratio.
Telephone support in the REEACT trial did not involve detailed explanations of cognitive behavioural therapy and did not involve detailed review of homework or tasks between sessions.
11 The level of support in the REEACT trial is one that is at least as intensive as that offered in many NHS care settings and is in line with (or in the case of MoodGYM exceeds) the level of support that is generally offered.
The trials in Barcelona were conducted in a specialist bipolar disorder service and the nature of the group support provided in the trials was not well characterised.
In addition, of those that had access to the Regul8 programme, half had no therapist support at all and half had one, 30 min telephone support session, whereas in the trial of the paper-based manual, one face to face and two telephone support sessions were offered to participants (3 hours in total).
29 The trial is funded by the Australian National Preventive Health Agency (reference: 95WOL2011) with in-kind support for the trial provided by Hunter New England Population Health.
Rather, this court "must indulge every fact and inference in support of the trial court's judgment, which is the equivalent of the jury verdict".
"When Mubarak was in court, it was the prosecution of a president who'd been around for 30 years, and those who were very vigorously in support of the trial really wanted a death sentence," said Hellyer.
