Exact(5)
Collectively, these reports support impaired β-cell function as an important pathophysiologic process underlying prediabetes and overt diabetes in youth.
Down-regulation of the putative Wnt-target genes vox, vent, but also otx2, sp5, and lim1 further support impaired Wnt-signaling.
Collectively, these findings support impaired nuclear recruitment of HDAC2 as a potential mechanism of steroid-resistant neutrophilic airway inflammation in asthma.
The results support impaired response control as a core deficit in adult ADHD with associated abnormal functional activation in the IFC.
As it is difficult to connect these observations with known substrates of Caspase-2 and the analysis of representative p53-induced genes failed to support impaired murine double minute 2 activity, as reported in cisplatin-treated lung cancer cells, we performed whole transcriptome analysis on premalignant Eμ-Myc pre-B cells lacking or expressing Caspase-2 (or Raidd).
Similar(55)
The idea of supporting impaired lung function with extracorporeal gas exchange in adults, however, was subsequently pursued by Kolobow et al [ 29].
Current evidence supports impaired cognitive development associated with lead concentrations < 10 µg/dL, and a nonlinear, inverse relationship between IQ and BLL has been established (with the greatest rate of IQ loss per unit blood lead < 10 µg/dL).
The diminished Cr levels associated with increased mean childhood blood lead levels further supported impaired neuronal functioning, because Cr levels are thought to reflect the status of cellular energetics.
At the same time, he is coordinating with a growing number of community groups that are stepping up to support students impaired by poverty.
These results strongly support an impaired neurogenesis together with a shift from neuronal to astroglial and oligodendroglial phenotype in Twin-DS-iPSC-derived cells.
Further evidence in support of impaired vascular tone may derive from our observed increase in collagen IV immunoreactivity in the microvasculature indicating an increase in the thickness of the basement membrane and hyalinosis, which might be related to endothelial cell and vascular smooth muscle cell dysfunction.
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