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All of these parameters involve mechanisms that include transcription factor synthesis, nuclear import and retention, posttranslational modifications of factors, and directing factors to subnuclear sites that support gene expression.
These data identify an essential role for smooth muscle signaling in the maintenance of epithelial architecture and support gene expression analyses and other studies that identify a role for stromal genes in cancer cell invasion.
Thus RNA self-splicing can occur at a rate sufficient to support gene expression in a prokaryote, despite the likely presence of ribosomes on the nascent RNA.
Along with Dr. Joseph Nevins, she has been successful in securing funding through various NIH sources to support gene expression studies and to develop computational tools for the analysis of gene expression data, as well as database systems for storage and further analysis of expression experiments.
These findings lead to the conclusion that an active chromatin structure is not sufficient to support gene expression, absent other elements within the barrier.
Although cAMP-dependent induction of multicellularity in D. discoideum has been studied intensively both biochemically and genetically, little is known about the transcription factors that support gene expression at the transition from growth to development.
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A bivalent state may explain the ability of gamma satellite to limit the spread of heterochromatin while simultaneously supporting gene expression [34].
Since RNMTcat is defective for supporting gene expression we investigated whether it is required for supporting cell proliferation.
It also supports gene expression analysis of any human Affymetrix expression platform, including exon arrays, and normalized gene counts from RNAseq data.
The EuroDia database was built using the Gene Expression Data Analysis Interface (GEDAI) framework, which supports gene expression data measured with Affymetrix gene chips, Agilent arrays, Illumina gene chips and custom spotted arrays.
Analysis at the protein level supported gene expression; immunofluorescent labelling of VIM and E-CAD revealed lack of E-CAD and positive VIM staining in NCAM1+ cells, whereas NCAM− cells showed wide spread E-CAD expression (Fig 2B and C).
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