The current study provides a safety assessment of multiple-dose administration of CAT-354 that supports further trials, and now efficacy studies are needed to evaluate the therapeutic potential of this drug.
We are sure that Ligtenberg and colleagues would agree with our conclusions: there is enough evidence to support further prospective trials comparing the clinical outcome of PICCs versus CVCs in ICU patients.
These preliminary findings reveal complex relationships between diet and therapeutic prevention, and they support further clinical trial-based investigations where the dietary intervention itself is controlled.
During this period, BT says it will support further development and/or trial of the chosen companies' wares.
Accumulating data from several trials support further evaluation of these candidate biomarkers and the potential predictive value of plasma VEGF-A is being evaluated prospectively in trials in other tumour types.
This time course and dose response study of alpha tocopherol in haemodialysis patients will provide data to support further large randomised controlled trials in this area.
Whether higher doses of mapatumumab would have led to more patients achieving a CR or PR is unknown, but safety data from other trials support further evaluation of higher doses.
The present results strongly support further large, multicenter clinical trials to evaluate the difference of the effects between DC and other means of craniotomy with proper evaluation, or of the effects of a combination with other methods such as hypothermia, of the therapies in acute post-traumatic BS after severe TBI [ 10, 24- 26, 31- 34].
Our results strongly support further large, multicenter clinical trials to examine the ways in which progesterone is achieving the profound neurologic effect and to decipher optimal conditions in which it can be used to lengthen the duration of and improve the degree of neuroprotection.
The findings presented here support further phase I/II clinical trials of immunotherapy with young TILs in patients with NPC in the near future.
