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Collectively, these results strongly support further optimization of this novel scaffold to develop better CXCR4 antagonists.
Collectively, these results strongly support further optimization of this novel scaffold to develop better Smo antagonists.
Collectively, these results strongly support further optimization of this novel scaffold to develop better Wnt pathway inhibitors.
These findings support further optimization efforts based on 18β-GA as a lead compound to develop potential anticancer drug candidates.
Bisperoxidovanadium (bpV, also: bisperoxovanadium) complexes inhibit PTEN activity and serve as model compounds to study these implications.[ 12– 16] The precise mode of action of bpV inhibitors is under debate,[ 13, 16] and its elucidation can support further optimization campaigns.
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This study may provide a support for further optimization of non-ATP-competitive Plk1 inhibitors.
The satisfaction assessment of emergency shelters can help government decision makers find low satisfaction areas of sheltering services and support further location-allocation optimization of urban emergency shelters.
Although the model is quite simple, these preliminary results point out that it may be an adequate tool to set design targets and support further steps of optimization.
Other proteases that produce small peptides were less reliable and produced a limited number of peptides (Table S-2, Supporting Information); however, further optimization of different cleavages could benefit focused studies by providing additional peptide labeling descriptions.
The data support promise for yoga-based interventions in prediabetes, and suggest that further optimization of intervention content and duration may be useful.
In order to obtain a robust process further optimization with respect to a suitable process strategy supporting both biomass formation as well as stable PHB production is required.
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