These findings lend support for variability of motor timing as endophenotype, though the accuracy of motor timing appears only to be associated with ADHD and not conclusively related to a familial susceptibility for the disorder (Fig. 1).
Finally, even though an in vivo cue reactivity study among adult smokers found support for variability in the susceptibility to environmental smoking cues among different DRD4 48 bp VNTR genotypes in relation to craving among adult smokers [ 10], this effect was not replicated in a study focusing on reactivity to dynamic smoking cues in movies among college students [ 78].
Additional support for phenotypic variability in yap mutants came from assessment of another allele, nl13, which exhibited a colobomatous phenotype (Fig. 2G-H) and was identified through a forward genetic screen of ENU-induced mutations.
When we applied the codon site models to the data set comprised of 70 Epd proteins (see Methods), we found that a LRT contrasting the site-models M0 and M3 was highly significant (p < 0.0001, [see additional file 5: Table_S4]), providing support for considerable variability in the selective pressures acting within the member genes of the Epd family.
However, we currently lack support for designing variability-intensive service-oriented systems.
It has been more formally suggested that IFN- γ activity is a continuous, genetically controlled trait with genetic variability in both production and responsiveness to IFN- γ [ 31], although there is little evidence to support a role for variability in IFN- γ production.
In conclusion, this study provides support for evaluating eGFR variability as an independent risk factor of dialysis/death, regardless of CKD stage.
Despite a few U.S. and international polls, there has been a notable paucity of academic research on examining public support for renewable energy, the variability in that support, and the factors behind that support or lack of support.
The results support the hypothesized steeper and shorter delay-of-reinforcement gradient in the animal model, and provided some support for the increased behavioral variability suggested by the dynamic developmental theory of ADHD: Behavior was more variable initially, decreased somewhat slower, and settled into comparable levels of variability only with extended training.
Regulatory regions, as demarcated by DNAse hypersensitivity sites, have been shown to be enriched for epigenetically variable loci (13), providing support for the conjecture that epigenetic variability may underlie altered expression patterns and thus modulate disease.
Discrepancies in nonverbal memory across the two awareness groups provide preliminary support for the idea that metamemory variability in AD may be related to the neuroanatomic presentation of the disease, with disordered awareness potentially reflective of a critical level of right hemisphere involvement.
