The approaches of MetFrag and Mass Frontier are complementary and have been used in combination to support structure elucidation [13, 14], but Mass Frontier does not perform candidate retrieval or scoring by itself.
The Cancer Genome Anatomy Project (CGAP) was designed and implemented to provide public datasets, material resources and informatics tools to serve as a platform to support the elucidation of the molecular signatures of cancer.
Therefore, it is mainly suited to study the secondary metabolism of a biological system of interest rather than to support the elucidation of primary metabolism.
In order to obtain additional information that could support the elucidation of their possible function and contribution to confer protection against acetic acid in the S. cerevisiae haa1∆ mutant, a prediction of conserved functional domains [ 19] and transmembrane helices (http://www.cbs.dtu.dk/services/TMHMM/) was attempted.
However, having no data supporting this, elucidation should be done cautiously.
Following grounded theory techniques the data analysis began as soon as the first interview transcripts were written and further sampling supported the elucidation of ideas and developed provisional theory [ 56].
Even today, the most abundant source of quantitative molecular data remains transcriptomic data, which can support hypothesis-free, elucidation of biological function (10).
Bisperoxidovanadium (bpV, also: bisperoxovanadium) complexes inhibit PTEN activity and serve as model compounds to study these implications.[ 12– 16] The precise mode of action of bpV inhibitors is under debate,[ 13, 16] and its elucidation can support further optimization campaigns.
In this article, we present an overview of the information content of UniProtKB/Swiss-Prot to show how this knowledgebase can support researchers in the elucidation of the mechanisms leading from a molecular defect to a disease phenotype.
Compelling evidence exists however supporting the need for elucidation of the role of negative lifestyle behaviours on the incidence of chronic pain, and the role of positive lifestyle behaviours on its incidence and effective management.
