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A scheme was proposed to support amplification in the band intensity of –C=O group in the PVA polymer in presence of NG.
Kurt et al. (31 ) reported that PMCA using human PrPC overexpressing transgenic mice brain (both 129M and 129V lines) as substrate failed to support amplification when seeded with CWD cervine brain homogenate.
The divergent molecular context of cellular networks that mediate glucocorticoid adverse effects (for example, corticotrophs or hepatocytes) do not support amplification, and therefore the safety profile of the very-low-dose glucocorticoid is maintained.
Cellular networks that mediate traditional glucocorticoid adverse effects do not support amplification of the low-dose glucocorticoid effect due to the absence of nodes or differential signaling pathway interactions, resulting in the selective action and an increased therapeutic window.
Dilutions of CWD brain homogenate in substrates prepared from human brain, transgenic mouse brain, and 239F cells expressing human PrP (129M or 129V) were compared for their ability to support amplification.
Of these, the majority of strains from whom complete PAI was amplified were from Japan (57%) whereas only 18.6% strains from Peru and 13.3% strains from Spain could support amplification of an intact cagPAI, due mainly to allelic diversity present at the primer annealing sites.
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Irrespective of origin, all 3 PRNP 129M-containing substrates supported amplification, albeit with slightly different efficiencies.
Yang et al. [ 41] showed that PIK3CA gene amplification was highly correlated with protein overexpression, supporting amplification as a major mechanism for overexpression.
All three PRNP 129V-containing substrates also supported amplification, although the level of amplification was lower than for the 129M equivalent.
Sound disperses among the bending live oaks or receives a measure of life support through amplification.
Such a system can support the amplification of the pulse with spectral width up to about 4660 cm−1-FWHM, which is the broadest in optical parametric chirped-pulse amplification (OPCPA) to our knowledge.
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