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These PK and dose-escalation findings support a dose of 750 mg once daily as the recommended phase II dose.
Given the relatively wide therapeutic index of meropenem, highly variable CrCL between ECMO patients based on modality and intensity of RRT used, loss in the ECMO circuit and preponderance of less susceptible organisms in this population especially with prolonged ECMO support, a dose of 1 g 8-hourly may be considered appropriate till more PK data becomes available.
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These results further support maintaining patients at a dose of 20 mg once daily down to a creatinine clearance of 30 mL/min [ 79].
Second, group sessions are implemented in both intervention programmes which provide a combination of social support, a healthy dose of competition and increase self-efficacy [ 52].
Among these, several lines of evidence support a dose-dependent effect of these drugs on angiogenesis; for example, in animal models, inflammation-induced angiogenesis is enhanced with low-dose statin therapy but inhibited at high statin concentrations, and high-dose statin concentration is associated with decreased tumor vascularization in a lung cancer model [2].
WASHINGTON — In the federal government's efforts to help farmers and ranchers survive this year's devastating drought, perhaps the most surprising step has been a dose of support for struggling producers of catfish.
The data from this study provide evidence to support a dose-dependent effect of prenatal stress on multiple aspects of brain development, potentially contributing to long-term outcomes.
This is supported by the simulation that a dose of 80 mg/m given qw has a higher ORR of 36.9% (95% CI: 32.1 41.8%), a longer median OS of 16.7 months (95% CI: 14.4 19.4), and a longer median PFS of 5.2 months (95% CI: 4.6 5.9), compared with the label dose of 175 mg/m given q3w.
Now, this belief has gotten a dose of scientific support from a study that suggests that the central nervous system can regulate pain and even reduce joint damage in arthritic rats.
At this time, other published studies support the use of levofloxacin at a dose of 500 mg every 12 hours in severe and life-threatening infections: an approved regimen in Europe but not yet approved in the United States (9, 10).
Our data support suppression of antibody titers at a dose of 30 mg/kg/day (Yang et al. 2002) and indicate that suppression of the primary antibody response occurs at a dose that is approximately 8-fold lower than reported by Yang et al. (2002).
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