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This seemed to be sufficient for the supply of intermediates for biosynthesis but might lead to unnecessary dissipation of ATP.
The oxidation of formate into NADH and CO2 by FDH may constitute a possible control mechanism to regulate the supply of intermediates to C1 metabolism.
SIRT3 appears to play a role in cellular energy production at multiple steps, i.e., up-regulation of fatty acid oxidation, supply of intermediates for the TCA cycle and activation of the electron transport chain (ETC).
Transcript levels of several enzymes of the glycolytic and alcohol fermentation pathways were examined in rice seedlings and it was reported that enzymes in this pathway have a sufficient degree of flexibility to adjust to increased energy demands and supply of intermediates for acclimatizing to higher temperatures [ 45].
Similar(55)
So long as you can count final goods, unmeasured improvements in the supply of intermediate services will succeed in raising measured productivity.
It is further demonstrated that the optimal strategy for the effective increase of network fluxes is through the coordinated amplification of a small number of steps in order to maintain maximum throughput while ensuring an uninterrupted supply of intermediate metabolites.
To approach this issue, an extra supply of intermediate metabolites in TCA cycle was made by conversion of aspartate to fumarate, a reaction mediated by the activity of l-aspartate ammonia-lyase (aspartase).
Identification of advanced crystalline intermediates enabled practical supply of key intermediates.
Following this line of thought, the feedback loop may represent a therapeutic target because it opens an opportunity to deprive cancer cells from their supply of metabolic intermediates.
Although oxidative phosphorylation (OxPhos) represents an efficient way to produce energy, proliferating tumour cells rely on increased aerobic glycolysis to produce energy, and a constant supply of metabolic intermediates to synthesise nucleotides and lipids.
Carbon wasting to other substances than acetate e.g. orotate, DHO, CBASP, NAA may be caused by an imbalance between the supply of precursors, intermediates of central metabolic network and insufficient use of them for the synthesis of biomass monomers and macromolecules which could be the result of energy limitations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com