Therefore, in considering early vitamin D supplementation, the question becomes whether there is physiological benefit to rapid replenishment with vitamin D (e.g. high doses of vitamin D in early life) with or without monitoring of 25(OH D levels or whether the 400 IU/day dose is adequate.
In words of Berger [ 15], "the efficiency of supplementation is a question of timing.
The REDOXs trial showed increased mortality with glutamine supplementation and raised questions whether critical illness is associated with low plasma glutamine levels at all [2] and whether interfering with glutamine supplementation could be deleterious [3].
These changes in tissue healing with tissue loading or IGF-I supplementation raise important questions regarding the essential role of mechanical stress for collagen matrix organization in connective tissues and the mechanisms by which systemic IGF-I or GH+IGF-I lead to improved tissue healing.
It is indeed an interesting question whether Supplementation (or perhaps Quasi-supplementation, as suggested by Gilmore 2015) is in some sense presupposed by the ordinary concept of gunk.
22 This difference causes us to question whether supplementation with n-3 in high dosages is really necessary.
Many studies have addressed the question of supplementation with antioxidant vitamins, especially vitamins C and E, and synthetic compounds can prolong the lifespan of model animals.
The effectiveness of vitamin A supplementation has also been questioned.
We took advantage of an on-going clinical study, the Trial of Infant Probiotic Supplementation (TIPS), to pose the question whether probiotic supplementation results in a species-specific increase in relative abundance that accounts for protection or if there is a global effect on the complex GI microbial consortium.
Thus, this brings into question L-arg supplementation as therapy without clear mechanistic evidence.
