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Compliance to the supplementation protocol was monitored by supplement logs and verbal confirmation.
After 3 weeks of each supplementation protocol, each participant then performed an acute resistance exercise challenge of 4 sets of 15 repetitions of squat/leg press at 50% 1-repetition maximum and continued supplementation over the recovery period that was evaluated.
All patients completed the 12 week supplementation protocol without side effects other than increased flatulence (N = 1).
Subjects tolerated the supplementation protocol well, with only one report of gastrointestinal distress (stomach cramps) on CrM+CLA but this did not lead to discontinuance of the study.
Although women have higher E2 concentrations than men, protein quantities of ERα and ERβ are similar and our supplementation protocol successfully increased circulating E2 to the level seen during the luteal phase of the menstrual cycle in healthy women [105], [106].
However, we note that, if the total amount of supplemental food is lower, more clumped, or supplied with lower frequency, or lower spatial predictability than in our supplementation protocol [16], a higher intensity of FS use by competitively dominant adult males may occur.
Similar(33)
The use of mtDNA depletion and supplementation protocols to improve embryonic development is supported by studies analysing the effect of the genetic distance between the donor cell and the recipient oocyte.
Furthermore, the combined supplementation induced a similar buffering potential to that of the sum of the individual supplementation protocols.
Investigations reporting potential side effects from prolonged (greater than 15 weeks) supplementation protocols have not been seen.
Therefore, the BA and SB supplementation protocols used in this study very likely promoted increased muscle carnosine and blood bicarbonate, respectively.
Detailed indices of fatty acid status are also of interest for assessing the efficacy of supplementation protocols.
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