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Because glutamine supplementation given to the right patients in the right doses may be helpful, this result imposes the risk of 'killing' the glutamine supplementation concept.
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Our present study with acute L-arginine supplementation further supports this concept by showing that short term L-arginine supplementation for 30 minutes enhances NO production.
One strategy to overcome this is supplementation with human cytokines; the concept is to create a more favorable immunologic environment for human cells within the mouse host.
The observed beneficial effects of recommended iron and folic acid supplementation in pregnancy validate the concept of pharmacovigilance system through HDSS.
Even the concept of micronutrient supplementation for pregnant women appears to be a universally accepted practice, and is widely accepted as 'insurance' to prevent adverse perinatal outcomes, especially in those at risk for inadequate nutrient status due to other health factors [ 9].
The essential concept of daily dietary supplementation with DHA, so that those at significant risk may be preloaded to provide protection against the acute effects of TBI, has tremendous public health implications".
Moreover, there is a need for feasible concepts to provide Se supplementation for large and/or moving flocks which are not able to provide daily oral administration of mineral supplements.
The anti-inflammatory properties of n-3 PUFA are not novel concepts, and the benefits of dietary supplementation with n-3 PUFA are well documented in several inflammatory and autoimmune diseases, including obesity [ 6, 7].
The concept of cardioprotection through omega-3 PUFA supplementation has been firmly engrained into the canon of medical knowledge and clinical thinking, as is evidenced by the AHA guidelines recommending intake of omega-3 PUFA [ 73].
The concept of β-cell recovery due to basal insulin supplementation has been developed several years ago [ 20].
Less common suggestions included supplementation with a wide range of micronutrients, coenzymes or amino acids (Bio Concepts-Cancer Update website).
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