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Nevertheless, in a combined analysis of the data from the same trial and a supplementary trial where metformin was given in combination with sulfonylureas, the effect of metformin on cardiovascular outcomes was not substantiated, due to increased cardiovascular mortality in the combination group (HR 1.96) (2).
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Studies within the program based on an Asian population were excluded, as were unpublished supplementary trials.
Otherwise, supplementary trials were proposed until two MVCs reproducible within 10% were obtained within a maximum of 5 trials.
14 15 We conducted a randomised, investigator blinded controlled supplementary feeding trial in Malawi to test the hypothesis that among wasted adults with HIV starting antiretroviral therapy, patients who receive the fortified spread for 14 weeks will have a greater increase in BMI and fat-free body mass than those receiving corn-soy blend.
This signal was not associated with activation during the effortful response either, as the same pattern of BOLD signal change was observed when including only the trials that were not followed by an effortful response period ("NO" trials and "No response required" trials; Supplementary Fig. 2 a ) in the fMRI analysis.
Endpoints were defined according to the opebacan protocol (Supplementary material: Opebacan trial protocol 06155).
Specific diets were designed manually by the team of dietitians for the purpose of the trial (Supplementary Table 2).
In addition, elevations in SBP were observed in the aforementioned concurrent phase IIa trial (Supplementary Table 1).
Although no Mcl-1cKO mice (n=8) produced litters after 4 months of age, two out of three Mcl-1c/ BaxDKO females produced at least one litter during the 3-month breeding trial (Supplementary Table S1).
We performed high-throughput miRNA expression profile of plasma samples from 18 lung cancer patients and 27 matched disease-free individuals grouped in 5 pools collected during the INT-IEO LDCT screening trial(Supplementary Table 1).
Similar results were observed for the combined effect of flavonol intake and serum cytokine concentrations at baseline (less significant effect) or during the trial (Supplementary Tables S2 and S3).
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